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Peters anomaly/Peters Plus syndrome
Background
Peters anomaly: Anterior Chamber Cleavage syndrome
Peters anomaly was first described in 1906 by a German Ophthalmologist, Dr Alfred Peters. The anomaly affects the eyes of people of both genders and from all ethnic groups. Peters anomaly is a developmental error of early pregnancy (10-16 weeks).
Normally, the cornea, which is the transparent 'window' of the eye, focuses light through the lens onto the retina (a light sensitive film at the back of the eye). Signals are then sent by the optic nerve to the brain for interpretation. The cornea, lens, retina and optic nerve need to work perfectly in harmony for clear vision.
In Peters anomaly the central part of the cornea is hazy and white. This may affect one or both eyes. The corneal opacity is the obvious feature that Dr Peters described but this is now known to be part of a spectrum of abnormal development of the front of the eye. The eye may be abnormal in other ways including the drainage angle of the eye which may be underdeveloped so there is a risk of glaucoma and the lens of the eye may be cloudy (see entry, cataracts). The fellow eye may have a milder developmental anomaly or be more severely affected where only a rudimentary small eye has developed.
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