Medical text written November 1991 by Contact a Family. Approved November 1991 by Professor M Patton, Professor of Medical Genetics, St Georges Hospital Medical School, London, UK and Dr J E Wraith, Consultant Paediatrician, Royal Manchester Children's Hospital, Manchester, UK. Last updated April 2004 by Professor A Zeman, Professor of Cognitive and Behavioural Neurology, Peninsula Medical School, Exeter, UK.