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Cutaneous mastocytosis; systemic mastocytosis
Mastocytosis is a disorder found in both children and adults, which results from too many mast cells in the body. Found in the skin, stomach lining, intestine and connective tissue (cartilage and tendons) they play an important role in helping your immune system to fight disease and infection. There are several types of mastocytosis recognized in the skin (cutaneous) while those that appear in internal organs are called systemic. Urticaria Pigmentosa (UP) is the most common cutaneous mastocytosis pattern and involves small pink or brown marks on the skin. The condition is usually more unsightly than harmful with some patients even improving naturally. Researchers first described Urticaria Pigmentosa in 1869. Systemic mastocytosis was first reported in the scientific literature in 1933. The true incidence of both types is unknown but it is a rare condition affecting one person in every 500,000.
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